In late fall, when the days get shorter, some people develop a special form of depression called seasonal affective disorder, or SAD. This condition should not be confused with mild winter blues. It is a real illness, as severely debilitating as any other form of clinical
Symptoms are generally worst in January and February, and begin to disappear as the days lengthen in the spring. SAD occurs most often in adolescents and women, but it is not limited to those groups. Up to 25% of the population may suffer from a mild version of SAD, and perhaps 5% experience the full disorder.
The cause of SAD is not known, but is believed to relate to the daily biological clock and the way it responds to sunlight. The hormones melatonin and serotonin are thought to be involved, although exactly in what manner remains unclear.
Conventional treatment for SAD focuses on increasing exposure to light. Making sure to get outside during the brightest part of the day may help significantly. Bright artificial light sources (phototherapy) are also helpful. Antidepressant drugs may be used if these treatments prove ineffective.
The body creates
when it is exposed to the sun, and during the winter vitamin D levels drop. For this reason, it seems logical that vitamin D supplements might help people with SAD. One
double-blind, placebo-controlled trial conducted during winter on 44 people without seasonal affective disorder found that vitamin D supplements produced improvements in various measures of mood.1 However, a double-blind, placebo-controlled study of 2217 women over seventy failed to find benefit.12 It has been suggested that phototherapy for SAD works by raising vitamin D levels, but current evidence indicates that this hypothesis is incorrect.2
melatonin plays a major role in the daily biological clock. Our bodies are designed to manufacture melatonin at night, and stop making it when the sun comes out. One study found that people with SAD had higher levels of melatonin than those without the condition.3 On this basis, it would seem that supplemental melatonin should worsen SAD symptoms. However, the evidence for such an effect is inconsistent.4 Some researchers have proposed that interaction between SAD and melatonin might be more complex than merely high or low levels, and that, when taken at certain times of day, melatonin might help the condition. A very small study found that when melatonin was given in the afternoon, it produced some benefit for people with SAD.5 However, a study of melatonin used in the early morning or the late evening failed to find any benefit.6
A small study failed to find
vitamin B12 helpful for SAD.7
St. John’s wort has shown considerable promise for treating depression in general. However, the evidence that the herb is helpful for SAD consists only of studies too preliminary to prove much.8,9Note:
Combining St. John’s wort with bright light therapy might not be safe. A substance called hypericin, found in most St. John’s wort products, may cause the body to become hypersensitive to light, increasing risk of damage to the skin and eyes. See the full article on
St. John’s wort
for more information.
For reasons that are not at all clear, use of a device that produces negative ions may help SAD symptoms, according to two preliminary controlled studies.10,11
Lansdowne AT, Provost SC. Vitamin D3 enhances mood in healthy subjects during winter.
Partonen T, Vakkuri O, Lamberg-Allardt C, Lonnqvist J. Effects of bright light on sleepiness, melatonin, and 25-hydroxyvitamin D(3) in winter seasonal affective disorder.
Biol Psychiatry. 1996;39:865–872.
Karadottir R, Axelsson J. Melatonin secretion in SAD patients and healthy subjects matched with respect to age and sex.
Int J Circumpolar Health. 2001;60:548–551.
Rosenthal NE, Sack DA, Jacobsen FM, et al. Melatonin in seasonal affective disorder and phototherapy.
J Neural Transm. 1986;21(Suppl):257–267.
Lewy AJ, Bauer VK, Cutler NL, Sack RL. Melatonin treatment of winter depression: a pilot study.
Psychiatry Res. 1998;77:57–61.
Wirz-Justice A, Graw P, Krauchi K, et al. Morning or night-time melatonin is ineffective in seasonal affective disorder.
J Psychiatr Res. 1990;24:129–137.
Oren DA, Teicher MH, Schwartz PJ, et al. A controlled trial of cyanocobalamin (vitamin B12) in the treatment of winter seasonal affective disorder.
J Affect Disord. 1994;32:197–200.
Martinez B, Kasper S, Ruhrmann S, et al. Hypericum in the treatment of seasonal affective disorders.
J Geriatr Psychiatr Neurol. 1994;7(Suppl 1):S29–S33.
Wheatley D. Hypericum in seasonal affective disorder (SAD).
Curr Med Res Opin. 1999;15:33–37.
Terman M, Terman JS. Treatment of seasonal affective disorder with a high-output negative ionizer.
J Altern Complement Med. 1995;1:87–92.
Terman M, Terman JS, Ross DC. A controlled trial of timed bright light and negative air ionization for treatment of winter depression.
Arch Gen Psychiatry. 1998;55:875–882.
Dumville JC, Miles JN, Porthouse J et al. Can vitamin D supplementation prevent winter-time blues? A randomised trial among older women.
J Nutr Health Aging. 2006;10:151-3.
Last reviewed August 2013 by EBSCO CAM Review Board
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