Substance Use Disorder

(Drug Abuse; Drug Addiction; Drug Dependence)


A substance use disorder refers to the ongoing use of a substance or drug even when faced with physical, emotional, or social harm.
Substances that are commonly misused include:
  • Caffeine
  • Tobacco
  • Alcohol
  • Marijuana
  • Methamphetamine (crystal meth, speed)
  • Cocaine
  • Heroin
  • Morphine
  • LSD
  • PCP
  • Ecstasy
  • GHB
  • Ketamine
  • Inhalants
  • Prescription medications that are used improperly such as steroids, opioid pain relievers, sedatives, sleeping pills, or amphetamines.
The addictive potential of each drug is different.


The exact cause of substance abuse disorder is unknown, but there are many theories. For example, some people may inherit certain genes that make them more likely to misuse substances. Another theory is that people learn how to use substances by copying the behavior of others, especially their parents. Also, changes that happen in the brain due to long-term use that may reinforce a person's desire to keep using the substance.
Chemical Release in Brain
Drugs stimulate unnecessary chemical release in the brain. Long-term drug use may change brain function.
Copyright © Nucleus Medical Media, Inc.

Risk Factors

Substance use disorder is more common in young men, but can occur in anyone at any age. Other factors that may increase the chances of substance use disorder:
  • Family members with substance use problems
  • Mental health conditions such as post-traumatic stress disorder , anxiety , depression , bipolar disorder , or panic disorder
  • Social and peer pressure to use substances, which may include spending time with other substance users
  • Early antisocial behavior such as breaking the law or repeated lying
  • Easy access to substances
  • Stress
  • Poor attachment to your parents or little parental supervision


Symptoms of substance use disorder include:
  • Poor ability to control substance use, including:
    • Taking the substance in much higher amounts for longer periods of time than intended
    • Inability to cut down or stop using the substance
    • Spending large amounts of time getting or using the substance, or recovering from using it
    • Craving the substance
  • Repeated work, school, home, or relationship problems due to substance use
  • Continued use of the substance even though it means risking physical safety, or knowing it will make existing physical or mental problems worse
  • Recurring trouble with the law related to substance use such as driving while under the influence of a substance or stealing to get the substance


Your doctor will ask you about your symptoms and medical history. A physical exam will be done.
Your doctor will also ask about:
  • Your history of substance use
  • Emotional problems that may have occurred while using a substance
  • Problems with work, school, homelife, or the law
Your doctor may order blood or urine tests to check for the presence of substances.


While there is no cure for substance use disorder, there are 3 main treatment goals:
  • To help you stop using the substance
  • Detoxification to decrease the toxic effects of the substances being used and to aid with symptoms of withdrawal
  • To prevent relapse
Successful treatment depends on you being able to recognize that you have a problem and having the desire to change. Recovery takes a long time. It is a difficult process. In some cases, you may need to go through treatment several times.
Treatment options may involve one or more of the following:


Medication may be recommended to help relieve withdrawal symptoms and reduce the risk of relapse.


Therapy can help raise your awareness of issues and lifestyle choices that lead you to misuse substances. Through therapy, you can improve your coping skills and problem-solving skills. You can also learn how to replace substance-using activities with healthier choices. It is also important that your family is involved in your treatment.

Support Groups

There are many organizations and support groups dedicated to helping people become substance-free. Two examples are the 12-step programs Narcotics Anonymous and Cocaine Anonymous. Members meet regularly to talk about their misuse problems and their recovery. They provide a network of support.


To help reduce your chances of substance use disorder:
  • Learn about risks related to substance use.
  • Do not spend time with people who are misusing substances.
  • Learn ways to handle peer pressure.
  • Have a good relationship with your children to help reduce their risk of substance use disorder.
  • Seek therapy for post-traumatic stress disorder , anxiety , depression , and other mental health problems.


Cocaine Anonymous 
Narcotics Anonymous 
National Institute on Drug Abuse 


Centre for Addiction and Mental Health 
Narcotics Anonymous 


Drugs, brains, and behavior: The science of addiction. National Institute on Drug Abuse website. Available at: Updated August 2010. Accessed April 17, 2018.
Opioid abuse and dependence. EBSCO DynaMed Plus website. Available at:  . Updated March 5, 2018. Accessed April 17, 2018.
Schinke SP, Fang L, Cole KC. Computer-delivered, parent-involvement intervention to prevent substance use among adolescent girls. Prev Med. 2009;49(5):429-435.
Substance use disorders (list of topics). EBSCO DynaMed website. Available at:  . Accessed April 17, 2018.
Treatment approaches for drug addiction. National Institute on Drug Abuse website. Available at: Updated January 2018. Accessed April 17, 2018.

Revision Information

  • Reviewer: EBSCO Medical Review Board Adrian Preda, MD
  • Review Date: 03/2018
  • Update Date: 04/17/2018
Article written by Wood D