Mesoglycan

Supplement Forms / Alternate Names

  • Aortic GAGs
  • Aortic Glycosaminoglycans

Introduction

Mesoglycan is a compound found in the intestines and blood vessels. It is taken from pigs or cows and made into a supplement. It has been used to increase blood flow. Mesoglycan can be applied to the skin, taken as a pill or injected into the muscle or bloodstream by a healthcare provider.

Dosages

100 milligrams once daily

What Research Shows

May Be Effective

Not Enough Data to Assess

  • Edema B1
Editorial process and description of evidence categories can be found at EBSCO NAT Editorial Process.
Editorial process and description of evidence categories can be found at EBSCO NAT Editorial Process.

Safety Notes

It may be safe to take mesoglycan by mouth for a short time. Not enough studies have been done to say whether it is safe to take for a long period or by women who are pregnant or breastfeeding. The FDA has also issued a warning against using supplements that contain animal products. D1
Interactions
Talk to your doctor about any supplements or therapy you would like to use. Some can interfere with treatment or make conditions worse.

References

A Diabetic Retinopathy
A1 Pacella E, Pacella F, et al. A pilot clinical study on the effectiveness of mesoglycan against diabetic retinopathy. Clin Ter. 2012;163(1):19-22.
B Edema
B1 Viliani T, Scarselli M, et al. Pharmacological treatment of mechanical edema: a randomized controlled trial about the effects of mesoglycan. Eur J Phys Rehabil Med. 2009 Mar;45(1):21-29.
C Intermittent Claudication
C1 Laurora G, Ambrosoli L, et al. Treatment of intermittent claudication with defibrotide or mesoglycan. A double blind study. Panminerva Med. 1994 Jun;36(2):83-86.
C2 Nenci GG, Gresele P, et al. Treatment of intermittent claudication with mesoglycan—a placebo-controlled, double-blind study. Thromb Haemost. 2001 Nov;86(5):1181-1187.
D Safety
D1 Important alert 17-04. Federal Drug Administration website. Available at: https://www.accessdata.fda.gov/cms%5Fia/importalert%5F53.html. Accessed May 29, 2019.
E Venous Ulcers
E1 Arosio E, Ferrari G, et al. A placebo-controlled, double-blind study of mesoglycan in the treatment of chronic venous ulcers. Eur J Vasc Endovasc Surg. 2001 Oct;22(4):365-372.

Revision Information

  • Reviewer: EBSCO NAT Review Board Eric Hurwitz, DC
  • Review Date: 03/2020
  • Update Date: 06/29/2020