Lutein

Introduction

Lutein is a compound found in green vegetables, yellow vegetables, and egg yolks. It has been used as an antioxidant to slow damage to cells. Lutein has also been used to improve vision and eye health. It can be taken as a pill or powder.

Dosages

6 milligrams 1 to 2 times daily

What Research Shows

Likely Effective

  • Cataract —likely to lower the risk of age-related cataract D1

May Be Effective

Not Enough Data to Assess

Editorial process and description of evidence categories can be found at EBSCO NAT Editorial Process.
Editorial process and description of evidence categories can be found at EBSCO NAT Editorial Process.

Safety Notes

It is likely safe to take lutein in small doses for a short time. Not enough studies have been done to say whether it is safe to take for a long period.
Interactions
Talk to your doctor about any supplements or therapy you would like to use. Some can interfere with treatment or make conditions worse.

References

A Amyotrophic Lateral Sclerosis
A1 Fitzgerald KC, O'Reilly ÉJ, et al. Intakes of vitamin C and carotenoids and risk of amyotrophic lateral sclerosis: pooled results from 5 cohort studies. Ann Neurol. 2013 Feb;73(2):236-245.
B Cardiometabolic Health
B1 Leermakers ET, Darweesh SK, et al. The effects of lutein on cardiometabolic health across the life course: a systematic review and meta-analysis. Am J Clin Nutr. 2016 Feb;103(2):481-494.
C Cardiovascular Disease
C1 Rees K, Dyakova M, et al. Dietary advice for reducing cardiovascular risk. Cochrane Database Syst Rev. 2013;(12):CD002128.
D Cataract
D1 Ma L, Hao ZX, et al. A dose-response meta-analysis of dietary lutein and zeaxanthin intake in relation to risk of age-related cataract. Graefes Arch Clin Exp Ophthalmol. 2014 Jan;252(1):63-70.
E Chronic Central Chorioretinopathy
E1 Salehi M, Wenick AS, et al. Interventions for central serous chorioretinopathy: a network meta-analysis. Cochrane Database Syst Rev. 2015 Dec 22;(12):CD011841.
E2 Shinojima A, Sawa M, et al. A Multicenter Randomized Controlled Study of Antioxidant Supplementation with Lutein for Chronic Central Serous Chorioretinopathy. Ophthalmologica. 2017;237(3):159-166.
F Macular Degeneration
F1 Ma L, Dou HL, et al. Lutein and zeaxanthin intake and the risk of age-related macular degeneration: a systematic review and meta-analysis. Br J Nutr. 2012 Feb;107(3):350-359.
F2 Wang X, Jiang C, et al. Role of lutein supplementation in the management of age-related macular degeneration: meta-analysis of randomized controlled trials. Ophthalmic Res. 2014;52(4):198-205.
F3 Liu R, Wang T, et al. Lutein and zeaxanthin supplementation and association with visual function in age-related macular degeneration. Invest Ophthalmol Vis Sci. 2014 Dec 16;56(1):252-258.
F4 Evans JR, Lawrenson JG. Antioxidant vitamin and mineral supplements for preventing age-related macular degeneration. Cochrane Database Syst Rev. 2017;7:CD000253.
F5 Evans JR, Lawreson JG. Antioxidant vitamin and mineral supplements for slowing the progression of age-related macular degeneration. Cochrane Database Syst Rev. 2017;7:CD000254.
G Non-Hodgkin Lymphoma
G1 Chen F, Hu J, et al. Carotenoid intake and risk of non-Hodgkin lymphoma: a systematic review and dose-response meta-analysis of observational studies. Ann Hematol. 2017 Jun;96(6):957-965.
H Respiratory Health
H1 Melo van Lent D, Leermakers ETM, et al. The effects of lutein on respiratory health across the life course: A systematic review. Clin Nutr ESPEN. 2016 Jun;13:e1-e7.
I Retinitis Pigmentosa
I1 Berson EL, Rosner B, et al. Clinical trial of lutein in patients with retinitis pigmentosa receiving vitamin A. Arch Ophthalmol. 2010;128(4):403-411.
I2 Brito-García N, Del Pino-Sedeño T, et al. Effectiveness and safety of nutritional supplements in the treatment of hereditary retinal dystrophies: a systematic review. Eye (Lond). 2017 Feb;31(2):273-285.

Revision Information

  • Reviewer: EBSCO NAT Review Board Eric Hurwitz, DC
  • Review Date: 03/2020
  • Update Date: 06/22/2020