MONDAY, Aug. 1 (HealthDay News) -- As if there weren't already
enough good reasons to avoid smoking and keep your weight, blood
sugar levels and blood pressure all under control, a new study
suggests these risk factors in middle age may cause your brain to
shrink, leading to mental declines up to a decade later.
Evaluating data from 1,352 participants whose average age was 54
in the Framingham Offspring Study -- which began in 1971 --
researchers from the University of California, Davis found that
smoking, high blood pressure, diabetes and being overweight were
each linked to potentially dangerous vascular changes in the
"We can't cure disease or cure aging, but the idea of a healthy body, healthy mind is very real," said study author Dr. Charles DeCarli, director of UC Davis' Alzheimer's Disease Center. "People should stop smoking, control their blood pressure, avoid diabetes and lose weight. It seems like a no-brainer."
The study is published Aug. 2 in the journal
Participants were given blood pressure, cholesterol and diabetes
tests and had their body mass and waist circumference measured.
They also underwent MRI brain scans over the course of a decade,
the first one about seven years after the initial risk factor
Those with stroke and dementia were excluded at the outset, and
between the first and last MRIs 19 participants suffered a stroke
and two developed dementia.
Those with high blood pressure experienced a more rapid
worsening of test scores of planning and decision-making, which
corresponded to a faster rate of growth of small areas of vascular
brain damage than those with normal blood pressure.
Those with diabetes in middle age experienced brain shrinkage in
an area known as the hippocampus faster than those without, and
smokers lost brain volume overall and in the hippocampus faster
than nonsmokers, with a more rapid increase of small areas of
vascular brain damage.
Meanwhile, participants who were obese at middle age were more
likely to be in the top 25 percent of those with faster declines in
tests of executive function, DeCarli said. Those with a high
waist-to-hip ratio were more likely to be among the 25 percent with
a faster drop in brain volume.
"I do think it's an important study and has practical importance in confirming there are things we can do in middle age that can have effects 10, 20 and 30 years down the line to improve cognitive health," said Dr. Raj Shah, medical director of the Rush Memory Clinic in Chicago. "It may seem we're talking about things that are somewhat common knowledge, but really, we always hypothesize these things could happen, but to show they actually do in a study is very important."
DeCarli noted that the effects of the risk factors studied are
likely to be even more compelling in the general population, since
study participants were largely healthy individuals with normal
blood pressure and cholesterol levels and a low diabetes rate.
"It could be so much worse in a representative group of Americans," he said, adding that all study participants were white and only 5 percent were diabetics, compared to a nearly 50 percent rate for Hispanics over age 65. And, "the study certainly doesn't represent the growing obesity problem seen in the South."
One of the strengths of the research was that it used a large
sample of people from a well-known study, said Catherine Roe, an
assistant professor of neurology at Washington University School of
Medicine in St. Louis. However, the results don't prove these risk
factors caused the brain changes, she added.
"We know smoking and being overweight are bad for other parts of your health," Roe said. "This is just one more reason to get these things under control."
The Alzheimer's Foundation of America has more about
the warning signs of dementia.
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