FRIDAY, May 4 (HealthDay News) -- A new study suggests that
severe weight gain might raise the risk for rheumatoid arthritis --
a painful, chronic ailment -- especially among obese women.
The epidemiological research indicated that about half of the
increase in rheumatoid arthritis cases in one Minnesota county may
be linked to rising obesity rates there over three decades.
"The findings outline yet another disease, or disease group, associated with the current obesity epidemic," said study co-author Dr. Sherine Gabriel. "We are likely to see an increasing incidence of rheumatoid arthritis as a result of the increasing prevalence of obesity if we don't address this health crisis."
Moreover, the research suggested that obesity precedes the onset
of rheumatoid arthritis, said Gabriel, a professor of medicine and
epidemiology at the Mayo Clinic in Rochester, Minn.
The impact of obesity on rheumatoid arthritis risk appeared
greater for women in the study, which may be due to the fact that
women get the disease three times more often than men. Men often
develop the condition later in life, according to the Arthritis
The study, conducted at the Mayo Clinic from 1985 to 2007,
appeared online recently in the journal
Arthritis Care & Research.
Rheumatoid arthritis affects about 1.3 million Americans, or 1
percent of the U.S. population, according to Arthritis Foundation
figures. The autoimmune disorder attacks joint tissues and
sometimes organs, causing swelling, inflammation, fever and
fatigue. The condition can develop at any time, but it usually
develops between the ages of 30 and 60.
The illness is influenced by both genetics and environmental
factors, according to background information in the study.
The new research was focused on Olmsted County, Minn., where
records of all medical providers have been collected on every
resident in one database for decades, Gabriel said.
Adults who developed rheumatoid arthritis were matched with
other people based on age, sex and year of diagnosis. Of the 813
people with the disease and another 813 without it, 68 percent were
women and about 30 percent were obese. Their average age was
Researchers reported that during the study the incidence of the
disease increased by about nine people per 100,000, and 52 percent
of the change was attributable to obesity.
Obesity rates in the United States have risen steadily, from
about 10 percent of the population in 1980 to almost 36 percent of
adults in 2007, according the U.S. Centers for Disease Control and
Prevention. About 17 percent of children are obese, the agency's
Commenting on the new findings, one expert expressed concerns
about increasing rates of rheumatoid arthritis fueled by rising
obesity rates, but agreed with the study's conclusion that more
research was needed because the Minnesota group was not racially
diverse. Olmsted County is 90 percent white, according to the
"The study was pretty well done," said Dr. Olivia Ghaw, a rheumatologist at Mt. Sinai Medical Center in New York City. But "the population was limited to one county, so I'm not sure the results can be extrapolated to the entire country."
Ghaw said that because rheumatoid arthritis is an inflammatory
disease and obesity has been linked to inflammation, a connection
between rising rates of both seemed likely.
"The increase in rheumatoid arthritis is troubling," she said. "Obesity confers a greater risk of inflammatory disease" because certain chemicals in fat cells promote inflammation in the body.
Ghaw also cautioned that treating obese patients for rheumatoid
arthritis might be more difficult because they may not respond as
well to the medications due to "a chronic inflammatory state."
On a positive note, she said the research showed that some
patients may be able to prevent the disease by keeping their weight
Although the study found an association between obesity rates
and rheumatoid arthritis, it did not prove a cause-and-effect
To learn more about rheumatoid arthritis, visit the
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